Regulation of membrane depolarization

Across TCGA patient cohorts, RNA activity of the Regulation of membrane depolarization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EFTUD2, TRIM21, and EVL, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane depolarization activity versus EFTUD2 in LSCC (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EFTUD2 →	-0.216	-0.053	<.001	<.001	3	8
OV	TRIM21 →	+0.315	+0.025	<.001	.004	3	7
HNSC	EVL →	+0.622	+0.050	<.001	.001	3	7
GBM	RSL1D1 →	-0.503	-0.067	<.001	<.001	3	7
LSCC	HSPA12B →	+0.325	+0.068	<.001	<.001	3	7
BRCA	NIP7 →	-0.480	-0.026	.003	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003254 vs EFTUD2 — LSCC

Explore this scatter interactively →