Regulation of membrane depolarization

Across TCGA patient cohorts, RNA activity of the Regulation of membrane depolarization pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK3, BCAS1, and SPATA6L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane depolarization activity versus ANK3 in CCRCC (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ANK3 →	+1.073	+0.666	<.001	<.001	3	7
GBM	BCAS1 →	+2.170	+0.826	<.001	<.001	3	5
LUAD	SPATA6L →	+0.433	+0.405	.004	<.001	3	4
LUAD	SIAE →	+0.622	+0.570	.001	<.001	3	4
LUAD	ARL4AP1 →	+0.620	+0.380	<.001	.001	3	4
LUAD	GJB1 →	+1.374	+0.417	.001	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003254 vs ANK3 — CCRCC

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