Regulation of membrane depolarization

Across TCGA cell cohorts, RNA activity of the Regulation of membrane depolarization pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RACK1, TDO2, and BAG5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RACK1 grouped by Regulation of membrane depolarization-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RACK1 →	-0.396	-0.773	<.001	.001	3	6
OESOPHAGUS	TDO2 →	-0.230	-0.315	<.001	<.001	3	4
OESOPHAGUS	BAG5 →	-0.220	-0.371	<.001	<.001	3	4
BLOOD_Leukemia	BTAF1 →	-0.305	-1.151	<.001	.006	3	4
SKIN	RING1 →	-0.180	-0.730	.002	.005	3	4
PANCREAS	AMPD1 →	-0.238	-0.300	.009	.009	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RACK1 by Regulation of membrane depolarization activity — BREAST

Explore this box plot interactively →