Regulation of membrane depolarization

Across TCGA cell cohorts, RNA activity of the Regulation of membrane depolarization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3R4, NOCT, and R3HDM4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIK3R4 grouped by Regulation of membrane depolarization-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PIK3R4 →	-0.548	-0.719	.001	.007	3	3
STOMACH	NOCT →	+1.088	+1.129	.007	.001	3	3
STOMACH	R3HDM4 →	-0.638	-0.840	.002	.005	3	3
SOFT_TISSUE	AGGF1 →	-0.432	-0.797	.001	.009	3	3
LIVER	FAM102A →	-1.483	-0.852	.007	.003	2	4
LARGE_INTESTINE	AKAP7 →	+1.410	+0.817	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIK3R4 by Regulation of membrane depolarization activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →