Regulation of membrane depolarization

Across TCGA cell cohorts, RNA activity of the Regulation of membrane depolarization pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS8, KDM5D, and DMRTC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LGALS8 grouped by Regulation of membrane depolarization-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LGALS8 →	+0.180	+0.325	.004	.002	3	3
STOMACH	KDM5D →	-0.097	-0.336	.003	<.001	3	3
LUNG_NSCLC_LUSC	DMRTC2 →	-0.282	-0.246	<.001	.005	3	3
STOMACH	TRIM49 →	-0.130	-0.313	.005	.007	3	3
OVARY	NSD1 →	-0.177	-0.185	.001	.004	3	3
BREAST	PRDM14 →	-0.167	-0.188	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LGALS8 by Regulation of membrane depolarization activity — STOMACH

Explore this box plot interactively →