Regulation of membrane depolarization

Across TCGA cell cohorts, RNA activity of the Regulation of membrane depolarization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC28B, THG1L, and NT5C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane depolarization activity versus CCDC28B in LIVER (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CCDC28B →	-1.044	-0.327	.001	.005	3	4
LUNG_NSCLC_LUAD	THG1L →	-0.465	-0.170	.009	.002	3	3
LUNG_NSCLC_LUAD	NT5C →	-0.858	-0.238	<.001	.001	3	3
LUNG_NSCLC_LUAD	CCDC169 →	-0.952	-0.214	.003	.002	3	3
KIDNEY	LRMDA →	-2.936	-0.395	.002	.002	3	3
KIDNEY	NPB →	+0.962	+0.286	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003254 vs CCDC28B — LIVER

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