Cardiac ventricle development

Across TCGA patient cohorts, RNA activity of the Cardiac ventricle development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SULF1, EFEMP2, and FHL3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac ventricle development activity versus SULF1 in LSCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SULF1 →	+0.907	+0.053	<.001	<.001	3	9
OV	EFEMP2 →	+0.735	+0.044	<.001	<.001	3	9
OV	FHL3 →	+0.823	+0.051	<.001	<.001	3	9
BRCA	SERPINF1 →	+0.694	+0.021	<.001	<.001	3	9
CCRCC	C8B →	+0.673	+0.041	<.001	<.001	3	9
LSCC	DPYSL3 →	+0.649	+0.054	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003231 vs SULF1 — LSCC

Explore this scatter interactively →