Cardiac ventricle development

Across TCGA cell cohorts, RNA activity of the Cardiac ventricle development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPGS1, WDR53, and BLOC1S2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TPGS1 grouped by Cardiac ventricle development-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TPGS1 →	+1.194	+0.328	.005	.001	3	4
STOMACH	WDR53 →	-0.784	-0.271	<.001	.004	3	4
STOMACH	BLOC1S2 →	+0.583	+0.218	.004	.001	3	4
SKIN	TAF12 →	-0.404	-0.183	.004	.003	3	4
BREAST	CHST3 →	-1.832	-0.165	<.001	.002	3	4
URINARY_TRACT	ITGBL1 →	-2.469	-0.297	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TPGS1 by Cardiac ventricle development activity — BONE

Explore this box plot interactively →