Ventricular cardiac muscle tissue development

Across TCGA patient cohorts, RNA activity of the Ventricular cardiac muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP9, DSP, and AIF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular cardiac muscle tissue development activity versus ARHGAP9 in BRCA (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGAP9 →	-0.784	-0.866	<.001	<.001	3	7
CCRCC	DSP →	+1.658	+0.686	<.001	.002	2	7
BRCA	AIF1 →	-0.619	-0.852	.004	<.001	3	6
COAD	CD14 →	-0.682	-0.424	.001	.006	3	5
BRCA	PKP2 →	+0.973	+0.603	<.001	.002	3	5
LSCC	DSC2 →	+1.285	+0.761	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003229 vs ARHGAP9 — BRCA

Explore this scatter interactively →