Ventricular cardiac muscle tissue development

Across TCGA cell cohorts, RNA activity of the Ventricular cardiac muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KAT8, ERI2, and USP39, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KAT8 grouped by Ventricular cardiac muscle tissue development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KAT8 →	+0.463	+0.637	.002	.002	3	5
LUNG_NSCLC_LUAD	ERI2 →	+0.534	+0.701	.001	.003	3	5
SOFT_TISSUE	USP39 →	+0.515	+1.086	.003	.003	3	5
KIDNEY	LTBP1 →	-1.334	-1.292	.001	.002	2	6
OVARY	NDUFAB1 →	+0.537	+0.769	<.001	.002	3	5
LUNG_NSCLC_LUAD	CCDC13 →	+0.173	+0.830	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KAT8 by Ventricular cardiac muscle tissue development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →