Ventricular cardiac muscle tissue development

Across TCGA cell cohorts, RNA activity of the Ventricular cardiac muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OVOL1, CBLC, and PRSS22, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular cardiac muscle tissue development activity versus OVOL1 in URINARY_TRACT (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OVOL1 →	+2.708	+0.618	.001	.001	3	9
LUNG_NSCLC_LUAD	CBLC →	+2.244	+0.795	<.001	<.001	3	8
LUNG_NSCLC_LUAD	PRSS22 →	+2.930	+0.886	<.001	<.001	3	7
PANCREAS	ITGB4 →	+2.458	+1.218	.008	.007	2	8
LUNG_NSCLC_LUAD	CNTNAP1 →	-1.569	-0.994	<.001	<.001	3	7
LUNG_NSCLC_LUAD	SH2D3A →	+1.578	+0.710	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003229 vs OVOL1 — URINARY_TRACT

Explore this scatter interactively →