Atrial cardiac muscle tissue development

Across TCGA patient cohorts, RNA activity of the Atrial cardiac muscle tissue development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMCN1, LAMB1, and PCOLCE, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrial cardiac muscle tissue development activity versus HMCN1 in OV (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HMCN1 →	+0.775	+0.051	<.001	.001	3	7
LSCC	LAMB1 →	+0.420	+0.068	<.001	<.001	3	7
CCRCC	PCOLCE →	+0.778	+0.093	.001	<.001	3	7
BRCA	OLFML3 →	+0.610	+0.047	<.001	<.001	3	7
COAD	SMOC2 →	+1.078	+0.082	<.001	.001	3	6
COAD	GULP1 →	+0.435	+0.041	.003	.004	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003228 vs HMCN1 — OV

Explore this scatter interactively →