Cardiac right ventricle morphogenesis

Across TCGA patient cohorts, RNA activity of the Cardiac right ventricle morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLEC11A, COL5A1, and MAP1A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac right ventricle morphogenesis activity versus CLEC11A in CCRCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CLEC11A →	+0.652	+0.067	<.001	<.001	3	9
BRCA	COL5A1 →	+1.066	+0.060	<.001	<.001	3	8
LSCC	MAP1A →	+0.478	+0.060	<.001	<.001	3	8
LSCC	APBB2 →	+0.326	+0.067	.001	<.001	3	8
CCRCC	ARHGEF17 →	+0.379	+0.071	<.001	<.001	3	8
CCRCC	AEBP1 →	+0.714	+0.088	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003215 vs CLEC11A — CCRCC

Explore this scatter interactively →