Cardiac right ventricle morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac right ventricle morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL44, TMEM59, and TEPSIN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPL44 grouped by Cardiac right ventricle morphogenesis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MRPL44 →	+0.539	+0.911	.001	<.001	3	5
PANCREAS	TMEM59 →	-1.005	-0.983	<.001	.001	3	4
LIVER	TEPSIN →	-0.586	-0.951	.001	.007	3	4
LIVER	RBM6 →	-0.582	-1.013	<.001	.003	3	4
CNS	ABHD3 →	-0.737	-0.602	.004	.009	3	4
PANCREAS	CST3 →	-0.823	-0.765	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPL44 by Cardiac right ventricle morphogenesis activity — LARGE_INTESTINE

Explore this box plot interactively →