Cardiac right ventricle morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac right ventricle morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDH2, PLEKHG4, and BBS4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac right ventricle morphogenesis activity versus CDH2 in CNS (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CDH2 →	+1.816	+1.390	.008	.002	2	4
CNS	PLEKHG4 →	-1.725	-1.157	.002	.002	3	3
OVARY	BBS4 →	+0.856	+1.933	.006	<.001	3	2
OVARY	NOLC1 →	+0.996	+1.742	.002	<.001	3	2
OVARY	ING2 →	+1.299	+2.153	<.001	.005	3	2
OVARY	PPID →	+1.279	+2.153	.006	.005	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003215 vs CDH2 — CNS

Explore this scatter interactively →