Cardiac ventricle formation

Across TCGA patient cohorts, RNA activity of the Cardiac ventricle formation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEOX2, MGP, and C7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac ventricle formation activity versus MEOX2 in LSCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MEOX2 →	+0.806	+0.168	<.001	<.001	3	6
HNSC	MGP →	+1.015	+0.319	.002	.001	3	5
LSCC	C7 →	+1.536	+0.224	<.001	<.001	3	5
HNSC	RECK →	+0.568	+0.338	<.001	<.001	3	5
HNSC	DUSP26 →	+0.981	+0.308	<.001	<.001	3	5
LUAD	SCN7A →	+1.151	+0.555	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003211 vs MEOX2 — LSCC

Explore this scatter interactively →