Cardiac ventricle formation

Across TCGA cell cohorts, RNA activity of the Cardiac ventricle formation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMF1, NPC2, and DTX3L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LMF1 grouped by Cardiac ventricle formation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LMF1 →	+2.400	+1.827	.003	.006	2	6
LUNG_NSCLC_LUAD	NPC2 →	-1.079	-0.950	.007	<.001	3	5
SOFT_TISSUE	DTX3L →	-1.395	-1.479	<.001	<.001	3	5
BREAST	B2M →	-1.499	-0.909	<.001	<.001	3	5
OESOPHAGUS	ZNF497 →	+1.076	+1.108	<.001	.008	3	5
BLOOD_Lymphoma	ZNF189 →	+0.866	+1.424	.004	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LMF1 by Cardiac ventricle formation activity — URINARY_TRACT

Explore this box plot interactively →