Cardiac ventricle morphogenesis

Across TCGA patient cohorts, RNA activity of the Cardiac ventricle morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BGN, CLEC11A, and CTHRC1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac ventricle morphogenesis activity versus BGN in OV (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BGN →	+0.944	+0.044	<.001	<.001	3	9
BRCA	CLEC11A →	+0.677	+0.026	<.001	<.001	3	9
OV	CTHRC1 →	+0.971	+0.045	.005	.001	3	9
OV	HMCN1 →	+0.795	+0.043	<.001	<.001	3	9
LUAD	COL3A1 →	+0.626	+0.030	<.001	.007	3	9
LSCC	GSN →	+0.700	+0.071	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003208 vs BGN — OV

Explore this scatter interactively →