Cardiac ventricle morphogenesis

Across TCGA patient cohorts, RNA activity of the Cardiac ventricle morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSP, C1orf162, and CD33, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac ventricle morphogenesis activity versus DSP in LUAD (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DSP →	+1.232	+0.675	<.001	<.001	3	7
COAD	C1orf162 →	-0.730	-0.617	<.001	.001	3	6
BRCA	CD33 →	-0.465	-0.538	.001	.002	3	6
BRCA	HCST →	-0.546	-0.458	<.001	<.001	3	6
BRCA	CD40LG →	-0.649	-0.696	.003	<.001	3	5
BRCA	PKP2 →	+1.364	+0.796	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003208 vs DSP — LUAD

Explore this scatter interactively →