Cardiac ventricle morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac ventricle morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MREG, DCAF10, and GCFC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MREG grouped by Cardiac ventricle morphogenesis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MREG →	+0.919	+0.970	.002	.002	3	6
STOMACH	DCAF10 →	-0.661	-1.213	.005	<.001	3	4
STOMACH	GCFC2 →	+0.880	+0.967	<.001	<.001	3	4
BONE	LOXL2 →	-3.656	-1.077	.005	.001	3	4
BONE	CD163L1 →	-1.741	-1.329	<.001	.001	3	4
SKIN	TGFBI →	-4.656	-0.678	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MREG by Cardiac ventricle morphogenesis activity — SOFT_TISSUE

Explore this box plot interactively →