Endocardial cushion morphogenesis

Across TCGA patient cohorts, RNA activity of the Endocardial cushion morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKD1, TBX3, and ZEB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cushion morphogenesis activity versus PRKD1 in CCRCC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PRKD1 →	+0.797	+0.328	<.001	<.001	3	7
BRCA	TBX3 →	+1.194	+0.254	<.001	<.001	3	6
BRCA	ZEB1 →	+0.792	+0.314	<.001	<.001	3	6
LSCC	ARHGEF40 →	+0.712	+0.306	<.001	<.001	3	6
UCEC	FOXS1 →	+1.040	+0.400	<.001	<.001	3	6
UCEC	TNFRSF19 →	+1.166	+0.315	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003203 vs PRKD1 — CCRCC

Explore this scatter interactively →