Endocardial cushion morphogenesis

Across TCGA cell cohorts, RNA activity of the Endocardial cushion morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHIC1, COQ8B, and EIF3H, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHIC1 grouped by Endocardial cushion morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CHIC1 →	-0.471	-0.741	.008	.009	3	4
BLOOD_Leukemia	COQ8B →	+0.757	+1.098	<.001	<.001	3	3
LUNG_NSCLC_LUSC	EIF3H →	+0.823	+1.290	.007	.004	3	3
KIDNEY	SULT1A4 →	+3.031	+1.354	.001	<.001	3	3
BLOOD_Lymphoma	EDEM3 →	-1.179	-1.972	.004	<.001	3	3
STOMACH	RPL22L1 →	+1.597	+0.851	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHIC1 by Endocardial cushion morphogenesis activity — CNS

Explore this box plot interactively →