Endocardial cushion development

Across TCGA patient cohorts, RNA activity of the Endocardial cushion development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF19, DKK3, and PRKD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cushion development activity versus TNFRSF19 in UCEC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TNFRSF19 →	+1.207	+0.293	.002	.001	3	6
LSCC	DKK3 →	+0.883	+0.337	<.001	<.001	3	6
CCRCC	PRKD1 →	+0.569	+0.316	<.001	<.001	3	6
GBM	ROBO2 →	+1.292	+0.455	.001	<.001	3	6
CCRCC	GUCY1A2 →	+0.838	+0.303	<.001	.001	3	6
BRCA	ZEB1 →	+0.910	+0.325	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003197 vs TNFRSF19 — UCEC

Explore this scatter interactively →