Endocardial cushion development

Across TCGA patient cohorts, RNA activity of the Endocardial cushion development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBX3_S707, TBX3_S456, and BIN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cushion development activity versus TBX3_S707 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TBX3_S707 →	+0.696	+0.296	<.001	<.001	3	6
BRCA	TBX3_S456 →	+0.965	+0.383	<.001	<.001	2	6
GBM	BIN2 →	-0.580	-0.443	<.001	<.001	3	5
UCEC	FARP1 →	+0.335	+0.356	<.001	<.001	3	5
OV	APC_S1042 →	+0.681	+0.379	<.001	<.001	3	5
UCEC	NADK →	-0.295	-0.317	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003197 vs TBX3_S707 — BRCA

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