Endocardial cushion development

Across TCGA cell cohorts, RNA activity of the Endocardial cushion development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PATE4, R3HCC1, and VPS35L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cushion development activity versus PATE4 in BREAST (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PATE4 →	-0.071	-1.263	.002	.005	3	4
BONE	R3HCC1 →	+0.707	+0.268	<.001	.006	3	3
OESOPHAGUS	VPS35L →	-2.139	-1.177	.001	.005	3	3
OESOPHAGUS	BCAS2 →	-0.820	-1.020	.001	.002	3	3
LUNG_NSCLC_LUSC	ATRX →	-1.128	-0.418	<.001	.005	3	3
CNS	MBD5 →	-0.686	-0.903	.003	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003197 vs PATE4 — BREAST

Explore this scatter interactively →