Atrioventricular valve formation

Across TCGA patient cohorts, RNA activity of the Atrioventricular valve formation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA20P1, SEPSECS-AS1, and IFI27L2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrioventricular valve formation activity versus SPATA20P1 in LUAD (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SPATA20P1 →	+0.876	+0.645	<.001	<.001	2	5
UCEC	SEPSECS-AS1 →	-0.437	-0.448	.002	.001	3	4
UCEC	IFI27L2 →	+0.898	+0.485	.007	.006	3	3
UCEC	EMILIN1 →	+1.054	+0.405	<.001	.004	3	3
UCEC	DZIP1L →	+1.380	+0.795	<.001	<.001	3	3
PDAC	SLC10A5 →	-0.574	-0.156	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003190 vs SPATA20P1 — LUAD

Explore this scatter interactively →