Atrioventricular valve formation

Across TCGA cell cohorts, RNA activity of the Atrioventricular valve formation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRX4, TAS2R7, and LANCL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IRX4 grouped by Atrioventricular valve formation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IRX4 →	+0.159	+0.208	<.001	.006	2	6
KIDNEY	TAS2R7 →	-0.364	-0.060	.001	.007	3	4
SKIN	LANCL2 →	-0.215	-0.159	<.001	<.001	3	4
URINARY_TRACT	SLPI →	-0.176	-0.247	<.001	<.001	3	3
URINARY_TRACT	GLCE →	+0.485	+0.309	.001	<.001	3	3
URINARY_TRACT	PRDM14 →	-0.150	-0.247	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IRX4 by Atrioventricular valve formation activity — LUNG_SCLC

Explore this box plot interactively →