Pulmonary valve morphogenesis

Across TCGA patient cohorts, RNA activity of the Pulmonary valve morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SGCD, VCAN, and BGN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pulmonary valve morphogenesis activity versus SGCD in BRCA (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SGCD →	+0.730	+0.065	<.001	<.001	3	9
OV	VCAN →	+1.106	+0.073	<.001	<.001	3	9
BRCA	BGN →	+0.717	+0.039	<.001	<.001	3	9
BRCA	CNN3 →	+0.568	+0.055	<.001	<.001	3	9
BRCA	FERMT2 →	+0.693	+0.076	<.001	<.001	3	9
OV	FHL3 →	+0.661	+0.076	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003184 vs SGCD — BRCA

Explore this scatter interactively →