Pulmonary valve morphogenesis

Across TCGA patient cohorts, RNA activity of the Pulmonary valve morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PEAK1, DSP_S2598, and ATAD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pulmonary valve morphogenesis activity versus PEAK1 in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PEAK1 →	+0.305	+0.328	<.001	<.001	3	4
OV	DSP_S2598 →	-1.859	-0.355	<.001	<.001	3	4
BRCA	ATAD1 →	-0.262	-0.160	<.001	<.001	3	3
OV	CCAR2_T484 →	+1.165	+0.463	<.001	<.001	3	3
BRCA	PLEKHG1 →	+0.374	+0.263	.002	<.001	2	4
LSCC	TPM2 →	+0.551	+0.367	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003184 vs PEAK1 — OV

Explore this scatter interactively →