Pulmonary valve morphogenesis

Across TCGA cell cohorts, RNA activity of the Pulmonary valve morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD40, POLR3D, and MTRNR2L8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANKRD40 grouped by Pulmonary valve morphogenesis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ANKRD40 →	+0.768	+1.140	.005	<.001	3	5
BONE	POLR3D →	+0.877	+1.225	.002	.004	3	4
CNS	MTRNR2L8 →	-0.330	-0.656	.005	.002	3	3
KIDNEY	CDC20 →	+0.982	+0.937	.004	<.001	3	3
KIDNEY	PKMYT1 →	+1.210	+1.319	<.001	<.001	3	3
KIDNEY	PLK4 →	+0.932	+1.014	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANKRD40 by Pulmonary valve morphogenesis activity — BLOOD_Leukemia

Explore this box plot interactively →