Pulmonary valve morphogenesis

Across TCGA cell cohorts, RNA activity of the Pulmonary valve morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD63, VPS13B, and FAM111A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pulmonary valve morphogenesis activity versus ANKRD63 in BONE (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ANKRD63 →	-1.766	-1.084	.001	.002	3	4
SOFT_TISSUE	VPS13B →	-0.892	-0.589	.009	.001	3	3
LUNG_SCLC	FAM111A →	-3.410	-0.485	.005	.009	2	4
SKIN	SLC25A15 →	-1.200	-0.406	<.001	.004	3	3
LARGE_INTESTINE	RFXAP →	-0.824	-1.485	.009	.005	3	3
LARGE_INTESTINE	CTTNBP2NL →	+0.558	+1.327	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003184 vs ANKRD63 — BONE

Explore this scatter interactively →