Pulmonary valve morphogenesis

Across TCGA cell cohorts, RNA activity of the Pulmonary valve morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JAG1, PSMB5, and LAMA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pulmonary valve morphogenesis activity versus JAG1 in OESOPHAGUS (Pearson r = 0.87).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	JAG1 →	+3.433	+1.901	<.001	<.001	3	6
BONE	PSMB5 →	-0.712	-0.696	.009	.007	3	4
BONE	LAMA1 →	-0.925	-0.907	.007	.009	3	4
BONE	LNPEP →	+0.949	+0.775	.001	<.001	3	4
BONE	SLC2A1 →	+1.511	+0.621	.003	.001	3	4
UPPER_AERODIGESTIVE_TRACT	CKAP4 →	+1.824	+1.822	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003184 vs JAG1 — OESOPHAGUS

Explore this scatter interactively →