Pulmonary valve development

Across TCGA patient cohorts, RNA activity of the Pulmonary valve development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNN3, FMNL3, and MMP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pulmonary valve development activity versus CNN3 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CNN3 →	+0.684	+0.069	<.001	<.001	3	9
CCRCC	FMNL3 →	+0.419	+0.091	<.001	<.001	3	9
BRCA	MMP2 →	+0.852	+0.060	<.001	<.001	3	9
CCRCC	ARHGEF17 →	+0.398	+0.092	<.001	<.001	3	9
LSCC	MAP1A →	+0.554	+0.061	<.001	<.001	3	9
OV	PRKG1 →	+0.801	+0.064	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003177 vs CNN3 — OV

Explore this scatter interactively →