Pulmonary valve development

Across TCGA patient cohorts, RNA activity of the Pulmonary valve development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCN4, LOX, and NFATC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pulmonary valve development activity versus CCN4 in BRCA (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCN4 →	+1.196	+0.243	<.001	<.001	3	6
LSCC	LOX →	+1.043	+0.379	<.001	.001	3	6
LSCC	NFATC1 →	+0.768	+0.319	<.001	<.001	3	6
LSCC	LOXL2 →	+1.180	+0.380	<.001	<.001	3	6
LSCC	PDGFRL →	+0.633	+0.248	<.001	.007	3	5
LSCC	COL12A1 →	+1.227	+0.321	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003177 vs CCN4 — BRCA

Explore this scatter interactively →