Pulmonary valve development

Across TCGA cell cohorts, RNA activity of the Pulmonary valve development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLX4IP, QPRT, and TTBK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pulmonary valve development activity versus SLX4IP in SKIN (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLX4IP →	+0.371	+0.347	.002	<.001	3	3
BREAST	QPRT →	-2.288	-0.788	.003	.008	3	3
BREAST	TTBK2 →	+0.671	+0.775	.002	.009	3	3
UPPER_AERODIGESTIVE_TRACT	IER3 →	+1.677	+1.330	.009	.003	3	3
BREAST	C12orf75 →	+2.831	+1.247	.005	.009	3	3
LUNG_NSCLC_LUAD	MTF2 →	+0.833	+0.506	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003177 vs SLX4IP — SKIN

Explore this scatter interactively →