Heart valve development

Across TCGA patient cohorts, RNA activity of the Heart valve development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL5A1, ADAMTS2, and MMP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart valve development activity versus COL5A1 in CCRCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	COL5A1 →	+1.151	+0.232	<.001	<.001	3	7
BRCA	ADAMTS2 →	+0.897	+0.227	<.001	<.001	3	6
BRCA	MMP2 →	+1.119	+0.261	<.001	<.001	3	6
BRCA	CPXM1 →	+1.463	+0.400	<.001	<.001	3	6
BRCA	PCOLCE →	+1.054	+0.360	<.001	<.001	3	6
CCRCC	COL1A1 →	+1.492	+0.239	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003170 vs COL5A1 — CCRCC

Explore this scatter interactively →