Heart valve development

Across TCGA cell cohorts, RNA activity of the Heart valve development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSL24D1, MRPL16, and MRM3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RSL24D1 grouped by Heart valve development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RSL24D1 →	+0.602	+0.891	.002	<.001	3	4
LARGE_INTESTINE	MRPL16 →	+0.731	+0.765	.004	.001	3	4
OVARY	MRM3 →	+0.945	+1.014	.002	.004	3	4
LUNG_NSCLC_LUAD	PPP2R3B →	-0.760	-0.646	.004	.005	3	4
LARGE_INTESTINE	AMZ2 →	-0.551	-0.530	.002	.007	3	4
UPPER_AERODIGESTIVE_TRACT	GOT2 →	+0.932	+1.006	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RSL24D1 by Heart valve development activity — OVARY

Explore this box plot interactively →