Heart valve development

Across TCGA cell cohorts, RNA activity of the Heart valve development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR179, CEP41, and PDK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart valve development activity versus GPR179 in SOFT_TISSUE (Pearson r = -0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GPR179 →	-0.052	-1.691	.002	<.001	3	4
BONE	CEP41 →	+1.296	+1.283	.006	.001	3	4
BONE	PDK1 →	+1.310	+1.551	.001	<.001	3	4
BLOOD_Lymphoma	HERC2 →	+0.718	+0.847	<.001	.001	3	4
BLOOD_Lymphoma	RARG →	-1.301	-0.793	.001	.002	3	4
BLOOD_Lymphoma	MRPL48 →	+0.749	+0.785	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003170 vs GPR179 — SOFT_TISSUE

Explore this scatter interactively →