His-Purkinje system development

Across TCGA cell cohorts, RNA activity of the His-Purkinje system development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ID2, RBM47, and HOOK1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, His-Purkinje system development activity versus ID2 in OVARY (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ID2 →	+3.047	+0.487	<.001	.001	3	16
STOMACH	RBM47 →	+2.230	+0.286	.001	.002	3	10
BREAST	HOOK1 →	+1.701	+0.291	<.001	<.001	3	9
BONE	LOXL2 →	-4.423	-0.286	<.001	<.001	3	9
URINARY_TRACT	NKX2-5 →	-2.193	-0.312	<.001	.004	3	9
BREAST	CTNNAL1 →	-1.189	-0.162	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003164 vs ID2 — OVARY

Explore this scatter interactively →