Sinoatrial node development

Across TCGA patient cohorts, RNA activity of the Sinoatrial node development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMCN1, RARRES2, and CLEC11A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sinoatrial node development activity versus HMCN1 in BRCA (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HMCN1 →	+0.513	+0.053	.001	.001	3	6
PDAC	RARRES2 →	+0.689	+0.045	<.001	<.001	3	6
CCRCC	CLEC11A →	+0.598	+0.604	.002	<.001	3	6
CCRCC	LTBP2 →	+0.753	+0.542	<.001	<.001	3	6
CCRCC	PDLIM5 →	+0.559	+0.610	<.001	<.001	3	6
BRCA	SSC5D →	+0.571	+0.049	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003163 vs HMCN1 — BRCA

Explore this scatter interactively →