Sinoatrial node development

Across TCGA patient cohorts, RNA activity of the Sinoatrial node development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX3, DTWD1, and NMRK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sinoatrial node development activity versus TBX3 in BRCA (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TBX3 →	+1.764	+0.838	<.001	<.001	3	6
BRCA	DTWD1 →	+0.367	+0.461	<.001	.001	3	4
CCRCC	NMRK1 →	+0.369	+0.171	<.001	.002	3	4
CCRCC	TMEM25 →	+0.694	+0.149	.001	.009	3	4
BRCA	TFF3 →	+3.571	+0.729	<.001	<.001	3	4
BRCA	SYNJ2BP →	+0.461	+0.543	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003163 vs TBX3 — BRCA

Explore this scatter interactively →