Sinoatrial node development

Across TCGA cell cohorts, RNA activity of the Sinoatrial node development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP29, FBXL15, and SMIM26, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP29 grouped by Sinoatrial node development-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ARHGAP29 →	-3.998	-1.593	.003	.001	3	4
BONE	FBXL15 →	+1.377	+1.685	.002	<.001	3	4
OESOPHAGUS	SMIM26 →	+1.045	+1.248	.001	.001	3	4
BONE	FLNC →	-2.941	-1.567	.005	<.001	3	3
STOMACH	RBMX →	+0.418	+0.953	.003	.006	3	3
STOMACH	DNAJC21 →	-0.924	-1.312	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP29 by Sinoatrial node development activity — BONE

Explore this box plot interactively →