Morphogenesis of an endothelium

Across TCGA patient cohorts, RNA activity of the Morphogenesis of an endothelium pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OLFML3, C1R, and C8A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of an endothelium activity versus OLFML3 in BRCA (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OLFML3 →	+0.932	+0.060	<.001	<.001	3	10
OV	C1R →	+0.632	+0.055	<.001	<.001	3	9
OV	C8A →	+0.624	+0.052	<.001	<.001	3	9
OV	C8B →	+0.603	+0.060	<.001	<.001	3	9
COAD	C8G →	+0.573	+0.055	<.001	<.001	3	9
BRCA	DCN →	+0.997	+0.057	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003159 vs OLFML3 — BRCA

Explore this scatter interactively →