Morphogenesis of an endothelium

Across TCGA patient cohorts, RNA activity of the Morphogenesis of an endothelium pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL16, ZNF624, and MS4A6A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of an endothelium activity versus IL16 in PDAC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IL16 →	+0.578	+0.380	<.001	<.001	3	4
PDAC	ZNF624 →	+0.295	+0.317	.004	.007	3	4
UCEC	MS4A6A →	+0.548	+0.186	.004	.004	3	4
COAD	FGL2 →	+0.731	+0.667	.002	.002	3	4
COAD	ENPP2 →	+0.868	+0.707	<.001	.004	3	4
COAD	PYHIN1 →	+0.520	+0.706	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003159 vs IL16 — PDAC

Explore this scatter interactively →