Morphogenesis of an endothelium

Across TCGA cell cohorts, RNA activity of the Morphogenesis of an endothelium pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OXCT1, ZNF414, and ZMYM4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of an endothelium activity versus OXCT1 in KIDNEY (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OXCT1 →	+1.874	+0.306	.008	.004	3	5
OESOPHAGUS	ZNF414 →	+0.586	+0.253	.006	.002	3	5
KIDNEY	ZMYM4 →	+0.758	+0.313	.006	.003	3	4
KIDNEY	H2BS1 →	-0.782	-0.443	.005	<.001	3	4
OESOPHAGUS	SLC12A4 →	+1.273	+0.279	.005	.006	3	4
PANCREAS	SLC9A5 →	+0.628	+0.261	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003159 vs OXCT1 — KIDNEY

Explore this scatter interactively →