Endothelium development

Across TCGA patient cohorts, RNA activity of the Endothelium development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SSC5D, COL15A1, and HSPG2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelium development activity versus SSC5D in CCRCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SSC5D →	+0.888	+0.061	<.001	<.001	3	10
PDAC	COL15A1 →	+0.555	+0.044	<.001	<.001	3	10
GBM	HSPG2 →	+0.511	+0.043	<.001	.002	3	10
UCEC	LAMA4 →	+0.677	+0.058	<.001	<.001	3	10
HNSC	LAMC1 →	+0.585	+0.065	<.001	<.001	3	10
BRCA	LUM →	+0.947	+0.036	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003158 vs SSC5D — CCRCC

Explore this scatter interactively →