Endothelium development

Across TCGA patient cohorts, RNA activity of the Endothelium development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASPA, IGSF21, and SGK1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelium development activity versus ASPA in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ASPA →	+0.499	+0.128	<.001	.005	3	2
BRCA	IGSF21 →	+1.079	+0.187	.005	<.001	3	2
BRCA	SGK1 →	+0.709	+0.176	.007	.007	3	2
BRCA	GLT8D2 →	+0.758	+0.147	.002	.001	3	2
BRCA	TPST2 →	+0.511	+0.156	.001	.005	3	2
BRCA	CCNB1 →	-0.667	-0.167	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003158 vs ASPA — BRCA

Explore this scatter interactively →