Endothelium development

Across TCGA cell cohorts, RNA activity of the Endothelium development pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOB, PDE9A, and FZD8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHOB grouped by Endothelium development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RHOB →	-0.149	-0.553	.001	.003	3	5
KIDNEY	PDE9A →	-0.383	-1.054	<.001	.001	3	5
OVARY	FZD8 →	-0.249	-0.684	.003	.008	2	6
LUNG_SCLC	RXRG →	-0.205	-0.169	.007	.003	3	4
OESOPHAGUS	CPT2 →	-0.284	-0.173	.008	.009	3	4
OVARY	TEF →	-0.294	-0.610	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHOB by Endothelium development activity — OVARY

Explore this box plot interactively →