Endothelium development

Across TCGA cell cohorts, RNA activity of the Endothelium development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM268, ZNF704, and ARHGAP22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM268 grouped by Endothelium development-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TMEM268 →	+1.636	+0.269	.007	.008	3	4
BLOOD_Myeloma	ZNF704 →	-0.774	-1.375	.006	.002	3	3
BLOOD_Leukemia	ARHGAP22 →	-2.101	-0.852	<.001	<.001	3	3
BLOOD_Leukemia	CFAP20 →	+0.433	+0.847	.006	<.001	3	3
OVARY	ATF4 →	+0.581	+0.747	.003	.006	2	4
URINARY_TRACT	RNF122 →	+0.921	+0.254	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM268 by Endothelium development activity — URINARY_TRACT

Explore this box plot interactively →