Endothelium development

Across TCGA cell cohorts, RNA activity of the Endothelium development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP2, PNPO, and LAD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelium development activity versus TJP2 in LUNG_SCLC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TJP2 →	+2.405	+0.248	.002	.005	2	6
LUNG_NSCLC_LUAD	PNPO →	+0.524	+0.189	.002	.006	3	5
LUNG_NSCLC_LUAD	LAD1 →	+2.442	+0.246	<.001	<.001	3	5
LUNG_SCLC	MPZL2 →	+2.276	+0.311	<.001	<.001	3	5
LUNG_SCLC	IL23A →	+1.915	+0.235	.005	.005	3	4
CNS	ZNF710 →	+0.521	+0.283	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003158 vs TJP2 — LUNG_SCLC

Explore this scatter interactively →